Why Do Amazon Natives Have Lower Rates of Dementia?
In a fascinating episode of The Dr. Mark Hyman Show, renowned medical expert Dr. Mark Hyman sits down with medical anthropologist and shamanic healer Alberto Villoldo to discuss groundbreaking insights into brain health.
The conversation unveils why only 1% of Amazonian natives experience dementia—a striking contrast to the 20% dementia rate in the United States—and what their ancient healing practices can teach us about protecting and regenerating the brain.
Growing a New Brain: The Science of Neurogenesis
One of the key takeaways from the discussion is that our brains are capable of regeneration. Villoldo explains how neurogenesis—the process of growing new neurons—occurs naturally but can be significantly enhanced with the right lifestyle choices.
Contrary to outdated beliefs, the brain does not remain static after a certain age but is constantly regenerating when given proper support.
The Power of NRF2 Activators and Sacred Plants
Villoldo introduces the concept of NRF2 activators—natural compounds that stimulate the body’s detoxification systems and promote cellular repair.
The indigenous people of the Amazon have long utilized sacred plants to activate these pathways, leading to enhanced longevity and cognitive resilience. Some of the most potent NRF2 activators include:
- Broccoli sprouts – Contain sulforaphane, a powerful detoxifier and anti-inflammatory compound.
- Turmeric (Curcumin) – A well-known anti-inflammatory agent that enhances brain function.
- Cat’s Claw – A plant used in traditional Amazonian medicine to boost immune and brain health.
The Gut-Brain Connection and Healing Through Diet
The discussion highlights the crucial role of gut health in maintaining a sharp mind.
Indigenous diets are rich in plant-based fibers, polyphenols, and essential nutrients, which support a healthy gut microbiome.
Modern diets, by contrast, are filled with processed foods and artificial additives that disrupt gut balance and contribute to inflammation—one of the leading causes of neurodegeneration.
Some key dietary interventions for brain health include:
- Omega-3 fatty acids (DHA from fish and algae) – Essential for neuroplasticity and brain repair.
- Fermented foods – Support gut health and serotonin production, which influences mood and cognition.
- Prebiotics and polyphenols – Found in pomegranates, green tea, and dark berries, these compounds feed beneficial gut bacteria and enhance cognitive function.
The Role of Trauma and Emotional Healing
Beyond diet, Villoldo emphasizes the impact of emotional trauma on brain health.
Stress, particularly chronic stress, leads to overproduction of cortisol, which damages the hippocampus—the brain’s memory center.
Indigenous healing practices, including meditation, breathwork, and shamanic rituals, aim to reset the nervous system and restore psychological well-being.
Psychedelics and Neuroplasticity
Psychedelic compounds like ayahuasca and psilocybin mushrooms, which have been used in Amazonian traditions for centuries, are now gaining recognition in modern neuroscience for their ability to promote neuroplasticity.
These substances act on serotonin receptors and have been shown to help individuals process trauma, reduce depression, and enhance cognitive flexibility.
Practical Steps to Improve Brain Health
For those looking to implement these Amazonian-inspired brain-healing techniques, Dr. Hyman and Villoldo suggest:
- Incorporating NRF2 activators into daily meals through cruciferous vegetables, turmeric, and other plant compounds.
- Adopting a ketogenic or intermittent fasting approach to trigger autophagy, the body’s natural detox process.
- Engaging in mindfulness and breathwork practices to regulate stress and support emotional healing.
- Supporting gut health with fermented foods, prebiotics, and polyphenol-rich superfoods.
- Exploring natural nootropics like omega-3s and adaptogenic herbs to optimize cognitive function.
Final Thoughts
The episode sheds light on the wisdom of indigenous healing traditions and how modern science is beginning to validate these ancient practices.
By integrating dietary interventions, emotional healing, and natural plant medicines, we can take proactive steps toward maintaining cognitive vitality and preventing neurodegenerative diseases.
For those interested in a deeper dive, Villoldo’s new book, Growing a New Brain, expands on these insights, providing practical tools for anyone looking to optimize brain health and longevity.
Watch full episode below:
